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Rapid detection of microbial DNA ... [Biochem Biophys Res Commun. 2012] - PubMed - NCBI
Biochem Biophys Res Commun. 2012 Apr 20;420(4):738-42. Epub 2012 Mar 17.
Rapid detection of microbial DNA by a novel isothermal genome exponential amplification reaction (GEAR) assay.
Prithiviraj J, Hill V, Jothikumar N.
Source
Georgia Tech, Institute of Bioengineering and Biosciences, 315 Ferst Drive, Atlanta, GA 30332, USA.
Abstract
In this study we report the development of a simple target-specific isothermal nucleic acid amplification technique, termed genome exponential amplification reaction (GEAR). Escherichia coli was selected as the microbial target to demonstrate the GEAR technique as a proof of concept. The GEAR technique uses a set of four primers; in the present study these primers targeted 5 regions on the 16S rRNA gene of E. coli. The outer forward and reverse Tab primer sequences are complementary to each other at their 5' end, whereas their 3' end sequences are complementary to their respective target nucleic acid sequences. The GEAR assay was performed at a constant temperature 60°C and monitored continuously in a real-time PCR instrument in the presence of an intercalating dye (SYTO 9). The GEAR assay enabled amplification of as few as one colony forming units of E. coli per reaction within 30min. We also evaluated the GEAR assay for rapid identification of bacterial colonies cultured on agar media directly in the reaction without DNA extraction. Cells from E. coli colonies were picked and added directly to GEAR assay mastermix without prior DNA extraction. DNA in the cells could be amplified, yielding positive results within 15min. Published by Elsevier Inc.
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May 9, 2012, NIAID Funding Newsletter
May 9, 2012
Feature Articles
Take Time to Size Up Potential Study Sections
Opportunities and Resources
Help Enhance and Evaluate Human Subjects Protections
In The News
File for a Change of Institution Electronically
News Briefs
FCOI Checklist for Institutions
NIAID Clarifies Areas of Interest for an R21/R33 RFA
NCATS Creates Web Sites for Its Rare Diseases Programs
Advice Corner
Don't Be Conflicted About Financial Conflicts of Interest
Reader Questions
In my progress report, do I need to justify an increase in my level of effort?
I'm a sixth-year postdoc. Should I apply for an NRSA Postdoctoral Fellowship (F32) when I move to another lab?
New Funding Opportunities
See the list
Take Time to Size Up Potential Study Sections
Proposing high-quality science is key to a successful application, but if that's your sole focus you're missing out on a big piece of the equation: getting the right peer reviewers. Even the most elegant science is not likely to impress reviewers who don't have your scientific perspective. You’ll need your reviewers’ enthusiasm to carry your application to a fundable score. So when you’re still picking a project, it’s helpful to know who shares your perspective and would best appreciate your work. Then when you write your application, you can keep those people in mind too. But because you can't control who reviews your application, you do need to write an application that appeals to a broad audience: your primary and secondary reviewers, including those you did not expect, and the others on the review panel. If some of those statements seem contradictory, they are. There are no simple answers, but keep reading to get our best advice. Research Your Reviewers Grant applications are no exception to the saying: beauty is in the eye of the beholder. Some reviewers are bound to deem your work boring, while others will find it exciting. Though it takes some intelligence-gathering, one strategy for success is to look for a study section that has reviewers in the latter category from the outset when choosing a topic.
Explore the perspectives and expertise of different standing study sections in light of the research you are planning.
Peruse the Roster Index for Regular Standing Study Sections and Continuing SEPs linked below to find a study section whose members seem to share your scientific perspective and whose work is most relevant to your field.
Read the descriptions, skim the rosters, and scan the lists of topics assigned to the various study sections.
After you find some good options, look at study section members in more depth, for example, by visiting their Web sites and reviewing their publications. You can use RePORTER to see what projects they have underway. Once you've looked at your reviewers, identify the three or so whose backgrounds and scientific records align best with your research area. While you can't know for certain who your reviewers will be, those closest to your field are most likely to be assigned as primary or secondary reviewers or readers, assuming you get your requested study section. Ask yourself how enthusiastic they and possibly the others may be about topics you are considering. Would they view a project as high impact? In their own publications, have they identified gaps your research would fill or areas of exploration that your work would pursue? Then choose a topic and write an application that meets their expectations so they’ll sit up and take notice. No Good Fit? Rethink It What happens if you don't find a good study section for the work you're contemplating? You could hunt down a "second best" study section, but first rethink your research. Consider modifying your project, changing your scope, or asking a different scientific question. Center for Scientific Review (CSR) has 184 standing study sections covering almost all areas of science, and that doesn't include special emphasis panels and institute-specific review groups. Your best bet is to carefully select a project that a study section can fully appreciate. For those who propose multidisciplinary and highly innovative work, read our advice on these types of projects:
Getting a Grant for Innovative Research
Team Science
Also consider contacting a program officer in your area of science for advice. If you don't know who that is at this point, take a step back and figure out where your project belongs. Read more at Pick a Research Project, linked below. Cover Yourself Once you've found the right reviewers for your application, aim to get your application in their hands: request your chosen study section in your cover letter. While that request can put the odds in your favor, there’s no guarantee CSR will assign your application to your top pick. As a fallback, also list the necessary expertise to review your application, in case CSR wants to assign it to a different panel. Get more advice in Create a Cover Letter, linked below. There are myriad reasons CSR can assign your application to a study section other than the one you request, for example, due to a reviewer conflict of interest or a scientific review officer who disagrees with your assessment of the science. Within 10 days after applying, log into the eRA Commons to check that your application is assigned to a study section with appropriate expertise. Ideally this will be the study section you requested, but CSR may have more than one study section that fits the bill and it sometimes creates ad hoc groups to fill in gaps. Later, once the actual roster appears in the Commons about 30 days before the review meeting, check that members have a track record or interest in your research. Rosters change from one review to the next as reviewers rotate on and off or miss a meeting. At any time, contact your scientific review officer to discuss your options if you're concerned with the study section assignment, expertise of study section members, or a reviewer who you feel cannot give your application an impartial review. For more information and advice, go to Ensure You Get the Right Assignments, linked below. Related Links CSR
Integrated Review Groups
Roster Index for Regular Standing Study Sections and Continuing SEPs
Strategy for NIH Funding
Part 2
Pick a Research Project
Part 3
Investigate Committees and Members
Know Your Audience
Part 4
Create a Cover Letter
Part 5
Ensure You Get the Right Assignments
NLM Databases and Electronic Resources—find publications NIH RePORTER—find funded projects, experts in your field, their publications and grants, and study sections that reviewed their applications
Help Enhance and Evaluate Human Subjects Protections
Help us help HHS with its plans to potentially revise the Common Rule (45 CFR 46, subpart A). Through a new funding opportunity announcement (FOA), you can contribute to enhancing the effectiveness of human subjects research protections while facilitating research and reducing the burden for investigators. Before you jump in, take note. This isn't a "come one, come all" FOA. That is, it limits competition by seeking only revision (aka, competing supplement) applications from grantees whose parent awards are active cooperative agreements when they apply. Consider responding if your research can contribute to either or both of these areas:
The effectiveness of current protections in regulations, rules, and policies governing research with human subjects.
The use of broad, prospective consent for acquiring biospecimens in clinical settings.
Read the April 20, 2012, Guide notice for more details. If you have questions, contact your program officer or NIH's Valery Gordon. Get answers as soon as possible since applications are due by May 25, 2012. For information on the proposal to improve the Common Rule, go to HHS's ANPRM for Revision to Common Rule.
File for a Change of Institution Electronically
If you’re considering a move to another organization, some news for you: on April 20, NIH launched a new pilot that allows electronic requests for a change of institution. You and the signing officials from both institutions can use the new pilot workflow in the Commons. Learn more in the Change of Institutions FAQs and get more details in the Commons Change of Institution user guide. The new process should be easier than the traditional method of filling out the PHS 3734 form and routing it manually through your institution to NIAID. As always, the eRA Help Desk welcomes your questions.
News Briefs
Here's news from around NIH. FCOI Checklist for Institutions. NIH released a Checklist for Financial Conflict of Interest Policy Development to help institutions construct and maintain comprehensive policies regarding financial conflicts of interest. Read the April 18, 2012, Guide notice for more information. NIAID Clarifies Areas of Interest for an R21/R33 RFA. New text in the Partnerships for Interventions to Treat Chronic, Persistent and Latent Infections (R21/R33) makes clear that applicants can propose approaches that seek to completely and permanently suppress an agent’s pathogenic processes without ongoing interventions. Get details in the May 1, 2012, Guide notice. NCATS Creates Web Sites for Its Rare Diseases Programs. The National Center for Advancing Translational Science published Web pages for two programs: Therapeutics for Rare and Neglected Diseases and Office of Rare Diseases Research.
Don't Be Conflicted About Financial Conflicts of Interest
With the release of NIH's Checklist for Financial Conflict of Interest Policy Development, we'd like to take the opportunity to mention again how important it is to disclose conflicts of financial interest—even potential ones—to your business office. Your institution has to manage, reduce, or eliminate all conflicts for you and your collaborators, and also ensure your subawardees comply with the NIH policy. Help it by knowing the rules and checking with your institutional official to see what you need to do. And be forewarned: we may suspend your research funding if your institution doesn't comply with NIH's conflict of interest policy. Read our Financial Conflicts of Interest for Awardees SOP for instructions, and visit NIH's Financial Conflict of Interest page for more information. Feel free to send us a question at deaweb@niaid.nih.gov. After responding to you, we may include your question in the newsletter, incorporate it into the NIAID Research Funding site, or both. "In my progress report, do I need to justify an increase in my level of effort"—Charles A. Paxton, University of Washington No. As long as the increase would not result in a change of scope, you do not need to justify it. If you're significantly increasing your effort, you may want to contact your program officer for advice on NIH rules you might need to follow, as well as other ways you may be able to support your research, e.g., by requesting an administrative supplement. "I'm a sixth-year postdoc. Should I apply for an NRSA Postdoctoral Fellowship (F32) when I move to another lab?"—anonymous reader While you can apply for an NRSA Postdoctoral Fellowship (F32) award in any year of your postdoctoral period, you would have to provide a very strong justification as to why you would still need mentored support at this point in your career. Instead, you may want to apply for an R01 grant and take advantage of new investigator benefits, such as a higher payline and lower expectations for preliminary data and publications. Read our New Investigator Guide to NIH Funding for advice and take a look at our R01 Investigator Resources.
PAR-12-182, Native American Research Centers for Health (NARCH)
See these and older announcements at NIAID Funding Opportunities List.
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AHRQ Innovations Exchange | Pediatric Asthma Care
Pediatric Asthma Care Pediatric asthma affects nearly 6 million children in the United States, reducing quality of life and often leading to costly emergency department visits and inpatient admissions. Low-income, urban children experience higher asthma-related morbidity due to environmental factors and poor access to appropriate care. Managing pediatric asthma according to existing guidelines can help minimize the potential for negative outcomes.
The featured Innovations describe one program that provided services to urban preschool children in an effort to improve asthma-related outcomes, and two programs that improved pediatric asthma care by increasing adherence to well-established care guidelines.
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AHRQ Innovations Exchange | Expert Commentary: National Academy and Affiliated State Chapters Support Pediatricians in Improving Asthma Care, Leading to Better Guideline Adherence and Disease Control, Fewer Acute Episodes
Innovation Profile:
National Academy and Affiliated State Chapters Support Pediatricians in Improving Asthma Care, Leading to Better Guideline Adherence and Disease Control, Fewer Acute Episodes
Pediatric Asthma Is a Worthy Quality Improvement Target
By Paul V. Williams, MD Northwest Asthma & Allergy Center
Efforts to improve pediatric asthma care are important, given the prevalence of the condition and its potential for causing adverse health outcomes. As a pediatric allergist, I’ve been involved in quality improvement in my own practice, though not specifically focused on adherence to asthma treatment guidelines. We can gain some insights into the challenges of quality improvement related to asthma care by considering two innovation profiles featured on the AHRQ Health Care Innovations Exchange. One profile—National Academy and Affiliated State Chapters Support Pediatricians in Improving Asthma Care, Leading to Better Guideline Adherence and Disease Control, Fewer Acute Episodes—describes a 1-year quality improvement project by the American Academy of Pediatrics (AAP) that helped 49 pediatric practices in 4 states to better adhere to established asthma care guidelines. The other profile—Mobile Clinic And In-Home Educator Generate Small, Short-Term Increases in Symptom-Free Days in Inner-City Preschool Children With Asthma But No Improvements in Other Key Outcomes—describes an attempt to use a mobile pediatric asthma clinic to improve asthma management among children enrolled in the Head Start program in Baltimore.
The pediatricians who organized the AAP initiative succeeded in what they tried to do, based on the impressive improvements in physician performance reported among the participating practices, with the percentage of patients receiving “optimal” care rising from 35 percent at baseline to 85 percent a year later. It appears that the practices—located in Alabama, Maine, Ohio, and Oregon—represent a reasonable cross-section of pediatric practices in the United States. It’s somewhat surprising that only 58 percent of the patients were considered to have well-controlled asthma at baseline, because you might expect that primary care pediatricians would tend to care for patients with relatively well-controlled, intermittent asthma. However, the practices may have tended to focus their quality improvement efforts on patients with a history of having less-than-optimal disease control.
After the intervention, 72 percent of the patients were classified as having well-controlled asthma, an outcome similar to results in other studies aimed at improving pediatric asthma care. As with other quality improvement studies, the key question is, what will happen to these patients over the long term? If the practices achieved lasting improvement in the asthma care process, the measured gains in physician performance could lead to long-term improvements in asthma control. In any case, if pediatricians in other settings can achieve even a fraction of the reported performance improvements, and demonstrate that the gains are sustainable, there’s a real potential for success. That’s why the AAP is continuing to support quality improvement initiatives that focus on asthma care.
Assuming that proper assessment of asthma severity and control has been accomplished, inadequate adherence to prescribed treatment is generally the main barrier to successful asthma management. We know that many patients who say that they are taking their medications actually haven’t filled or refilled their prescriptions, but their physicians often lack a good way to assess adherence. Even in practices like my own that use an electronic health record system, the infrastructure often is not yet in place to enable electronic communication with pharmacies.
The mobile pediatric asthma clinic that was used in the Baltimore program was introduced in 1995 in Los Angeles. The original Breathmobile program achieved some great successes by taking care to the patients. Back in the 1990s, though, it was probably easier to make a big difference in asthma care. After all, it was only in 1991 that the National Asthma Education and Prevention Program had distributed its initial guidelines on diagnosis and management of asthma, in response to the lack of standardization in asthma care. By 2005, when Baltimore’s Breathmobile program began serving children enrolled in Head Start, the level of asthma care may have been fairly good already. And given the low rates of family participation, we shouldn’t be surprised that the program had such a limited impact on patient outcomes.
Asthma diagnosis is difficult in preschool children, because young children have great variability in disease expression and are not developmentally able to undergo spirometry assessments. Also, we have relatively few data on treatment efficacy in preschool children and their symptoms often improve spontaneously. Although these factors can make it difficult to assess the value of early intervention, efforts to identify and treat high-risk populations are worth pursuing as we seek to address unmet needs for effective care among children with asthma. About the Author:
Paul V. Williams, MD, is an allergy and asthma specialist at the Mount Vernon, WA, office of the Northwest Asthma & Allergy Center. He is a member of the Board of Directors of the Joint Council on Allergy, Asthma and Immunology, and represents the American Medical Association on the National Asthma Education and Prevention Panel.
Disclosure Statement: Dr. Williams has been involved in a variety of leadership roles with the American Academy of Pediatrics, which developed the asthma care quality improvement project described in the innovation profile about the AAP initiative.
Original publication:May 09, 2012. Original publication indicates the date the profile was first posted to the Innovations Exchange.Last updated:May 09, 2012. Last updated indicates the date the most recent changes to the profile were posted to the Innovations Exchange.
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full-text ►
National Guideline Clearinghouse | ACR Appropriateness Criteria® ductal carcinoma in situ.
Guideline TitleACR Appropriateness Criteria® ductal carcinoma in situ.Bibliographic Source(s)
Moran MS, Bai HX, Haffty BG, Harris EER, Arthur DW, Bailey L, Bellon JR, Carey L, Goyal S, Halyard MY, Horst KC, MacDonald SM, Expert Panel on Radiation Oncology-Breast. ACR Appropriateness Criteria® ductal carcinoma in situ. [online publication]. Reston (VA): American College of Radiology (ACR); 2011. 14 p. [52 references]
Guideline StatusThis is the current release of the guideline.
This guideline updates a previous version: Rabinovitch R, Solin LJ, Shank BM, Green S, Haffty BG, Halberg FE, Mitchell SE, Strom EA, Taylor ME, White JR, Cobleigh MA, Edge SB, Mauch PM, Expert Panel on Radiation Oncology-Breast Work Group. Ductal carcinoma in situ. [online publication]. Reston (VA): American College of Radiology (ACR); 2006. 15 p.
The appropriateness criteria are reviewed biennially and updated by the panels as needed, depending on introduction of new and highly significant scientific evidence.
To contact us Click HERE full-text ► National Guideline Clearinghouse | ACR Appropriateness Criteria® external beam radiation therapy treatment planning for clinically localized prostate cancer.
Abdel-Wahab M, Mahmoud O, Merrick G, Hsu IC, Arterbery VE, Ciezki JP, Frank SJ, Mohler JL, Moran BJ, Rosenthal SA, Rossi CJ II, Yamada Y, Expert Panel on Radiation Oncology-Prostate. ACR Appropriateness Criteria® external beam radiation therapy treatment planning for clinically localized prostate cancer. [online publication]. Reston (VA): American College of Radiology (ACR); 2011. 13 p. [133 references]
Guideline StatusThis is the current release of the guideline. This guideline updates a previous version: Michalski JM, Roach M III, Merrick G, Anscher MS, Beyer DC, Lawton CA, Lee WR, Pollack A, Rosenthal SA, Vijayakumar S, Carroll PR, Expert Panel on Radiation Oncology-Prostate. External beam radiation therapy treatment planning for clinically localized prostate cancer. [online publication]. Reston (VA): American College of Radiology (ACR); 2006. 12 p. The appropriateness criteria are reviewed biennially and updated by the panels as needed, depending on introduction of new and highly significant scientific evidence.
Konski AA, Suh WW, Blackstock AW, Herman JM, Hong TS, Poggi MM, Rodriguez-Bigas M, Small W Jr, Thomas CR Jr, Zook J, Expert Panel on Radiation Oncology-Rectal/Anal Cancer. ACR Appropriateness Criteria® recurrent rectal cancer. [online publication]. Reston (VA): American College of Radiology (ACR); 2011. 9 p. [43 references]
Guideline StatusThis is the current release of the guideline. This guideline updates a previous version: Konski AA, Herman J, Suh WW, Blackstock AW, Mohiuddin M, Poggi MM, Regine WF, Rich TA, Cosman BC, Saltz L, Expert Panel on Radiation Oncology-Rectal/Anal Cancer. ACR Appropriateness Criteria® recurrent rectal cancer. [online publication]. Reston (VA): American College of Radiology (ACR); 2008. 7 p. The appropriateness criteria are reviewed biennially and updated by the panels as needed, depending on introduction of new and highly significant scientific evidence.
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HERE ► Bipolar Disorder: MedlinePlus
Bipolar treatment: Are bipolar I and bipolar II treated differently? - MayoClinic.com
Bipolar Disorder
Also called: Manic-depressive illness Share on facebookShare on twitter Bipolar disorder is a serious mental illness. People who have it experience dramatic mood swings. They may go from overly energetic, "high" and/or irritable, to sad and hopeless, and then back again. They often have normal moods in between. The up feeling is called mania. The down feeling is depression. Bipolar disorder can run in families. It usually starts in late adolescence or early adulthood. If you think you may have it, tell your health care provider. A medical checkup can rule out other illnesses that might cause your mood changes. Untreated, bipolar disorder can result in damaged relationships, poor job or school performance, and even suicide. However, there are effective treatments: medicines and "talk therapy". A combination usually works best. NIH: National Institute of Mental Health
MEDICAL ENCYCLOPEDIA
Bipolar disorder
Cyclothymic disorder
Related Topics
Depression
Mental Health and Behavior
National Institutes of Health
The primary NIH organization for research on Bipolar Disorder is the National Institute of Mental Health
To contact us Click HERE U.S. Food and Drug Administration Office of Special Health Issues 10903 New Hampshire Avenue Silver Spring, Maryland 20993
Dear Colleague,
As part of our ongoing efforts to keep you informed about FDA issues, we want to make you are aware of recent safety alerts, announcements, opportunities to comment on policy issues, product approvals, upcoming meetings, and resources. We have included a list of the issues, a brief summary of each issue, and links to detailed information on the FDA Web site.
PRODUCT SAFETY: Revlimid (lenalidomide): Ongoing Safety Review - Increased Risk of Developing New Malignancies (May 7) FDA notified the public of an increased risk of second primary malignancies in patients with newly-diagnosed multiple myeloma who received Revlimid. Victrelis (boceprevir) and Ritonavir-Boosted Human Immunodeficiency Virus (HIV) Protease Inhibitor Drugs: Drug Safety Communication - Drug Interactions (Apr 26) FDA notified healthcare professionals that the Victrelis drug label has been revised to state that co-administration of Victrelis (boceprevir), a hepatitis C virus protease inhibitor, along with certain ritonavir-boosted human immunodeficiency virus protease inhibitors, is not recommended. For more product safety information, please visit our MedWatch website at http://www.fda.gov/medwatch
PRODUCT APPROVALS: FDA permits marketing of a new device for abdominal surgery (May 1) FDA allowed marketing of the first surgical instrument set that can be assembled and disassembled inside the body during surgery. FDA approves new orphan drug to treat a form of Gaucher disease (May 1) FDA approved Elelyso (taliglucerase alfa) for long-term enzyme replacement therapy to treat a form of Gaucher disease, a rare genetic disorder. FDA approves new antibacterial treatment for plague (Apr 27) FDA approved Levaquin (levofloxacin) to treat patients with plague, a rare and potentially deadly bacterial infection. FDA approves Stendra for erectile dysfunction (Apr 27) FDA approved Stendra (avanafil), a new drug to treat erectile dysfunction. FDA approves Votrient for advanced soft tissue sarcoma (Apr 26) FDA approved Votrient (pazopanib) to treat patients with advanced soft tissue sarcoma who have previously received chemotherapy. FDA approves Afinitor for non-cancerous kidney tumors caused by rare genetic disease (Apr 26) FDA approved Afinitor (everolimus), the first drug approved specifically to treat non-cancerous kidney tumors not requiring immediate surgery in patients with tuberous sclerosis complex. For information on drug approvals, please visit Drugs@FDA OPPORTUNITIES FOR COMMENT AND/OR RECENTLY PUBLISHED GUIDANCES:
Draft Guidance for Industry and Food and Drug Administration Staff - Pediatric Information for X-ray Imaging Device Premarket NotificationsThe Agency intends for this guidance to minimize uncertainty during the premarket review process of 510(k)s for x-ray imaging devices for pediatric use, to encourage the inclusion of pediatric indications for use for x-ray imaging device premarket notifications, and to provide recommendations on information to support such indications. Submit either electronic or written comments on the draft guidance by September 7, 2012. Agency Information Collection Activities; Submission for Office of Management and Budget Review; Comment Request; Revisions to Labeling Requirements for Blood and Blood Components, Including Source PlasmaUnder this rulemaking, FDA is consolidating the regulations related to labeling blood and blood components. Fax written comments on the collection of information by May 25, 2012. Agency Information Collection Activities; Proposed Collection; Comment Request; Medical Device Decision Analysis: A Risk-Tolerance Pilot StudyThis notice solicits comments on the survey entitled “Medical Device Decision Analysis: A Risk-Tolerance Pilot Study.” Submit either electronic or written comments by June 18, 2012. Agency Information Collection Activities; Proposed Collection; Comment Request; Guidance for Industry, FDA Staff, and Foreign Governments: Fiscal Year 2012 Medical Device User Fee Small Business Qualification and CertificationThis notice solicits comments on Form FDA 3602 and Form FDA 3602A, which will allow domestic and foreign applicants to certify that they qualify as a “small business” and pay certain medical device user fees at reduced rates. Submit either electronic or written comments by June 18, 2012. Proposed Collection; Comment Request; Financial Disclosure by Clinical InvestigatorsThis notice solicits comments on information collection on financial disclosure by clinical investigators. Submit either electronic or written comments by May 29, 2012. Comment Request; Experimental Study of Graphic Cigarette Warning Labels This notice solicits comments on the Experimental Study of Graphic Cigarette Warning Labels that is being conducted in support of the graphic label provision of the Family Smoking Prevention and Tobacco Control Act. Submit either electronic or written comments by May 29, 2012. Comment Request; Adverse Event Reporting and Recordkeeping for Dietary Supplements as Required by the Dietary Supplement and Nonprescription Drug Consumer Protection Act This notice solicits comments on the collection of information associated with adverse event reporting and recordkeeping for dietary supplements as required by the Dietary Supplement and Nonprescription Drug Consumer Protection Act. Submit either electronic or written comments by May 22, 2012. Draft Guidance for Industry: Direct-to-Consumer Television Advertisements -- FDAAA DTC Television Ad Pre-Dissemination Review Program This draft guidance is intended to assist sponsors of human prescription drug products, including biological drug products, who are subject to the pre-dissemination review of television advertisements provision of the FD&C Act. Submit either electronic or written comments by May 14, 2012. Draft Guidance for Industry on Limiting the Use of Certain Phthalates as Excipients in Center for Drug Evaluation and Research-Regulated Products This draft guidance provides the pharmaceutical industry with CDER's current thinking on the potential human health risks associated with exposure to DBP and DEHP. Submit either electronic or written comments on the draft guidance by May 31, 2012.
ANNOUNCEMENTS:
FDA proposal aims to help reduce unnecessary radiation exposure for children (May 9) FDA announced that it is seeking public comment on a proposal encouraging manufacturers to consider the safety of children in the design of new X-ray imaging devices. FDA Launches New E-Lists for Cardiovascular Disease and Diabetes (May 7) Sign up to receive FDA updates on safety and regulatory issues related to Cardiovascular Disease and Diabetes, including product approvals, safety warnings, notices of upcoming public meetings, and notices about proposed regulatory guidances. FDA issues final rule on sterility testing of biological products (May 3) FDA issued its final rule on sterility testing, amending the requirements for most licensed biological products. The action follows a retrospective review of agency regulations to promote improvement and innovation and is in response to Executive Order 135631 that is designed to improve regulation and regulatory review. FDA challenges marketing of DMAA products for lack of safety evidence (Apr 27) FDA issued warning letters to ten manufacturers and distributors of dietary supplements containing dimethylamylamine, more popularly known as DMAA, for marketing products for which evidence of the safety of the product had not been submitted to FDA. Webinar: Practical Advice for Preventing Surgical Fires--Safety Strategies from the Front Lines (Apr 26) FDA experts will briefly discuss the ‘Preventing Surgical Fires’ Initiative. Invited hospital staff will share their experiences and protocols used to prevent surgical fires. Surgical Fire prevention recommendations will also be presented. Recent Spanish versions of Drug Safety Communications: (Given various time and review constraints, availability of Spanish language versions of Drug Safety Communications will generally follow the English version by about 1-2 weeks.) - Comunicado de la FDA sobre la seguridad de los medicamentos: Información actualizada sobre la interacción entre el medicamento Victrelis (boceprevir) y ciertos medicamentos reforzados inhibidores de la proteasa del VIH - Comunicado de la FDA sobre la seguridad de los medicamentos: Nueva advertencia y contraindicación sobre medicamentos para la presión arterial que contienen aliskiren
UPCOMING MEETINGS: Endocrinologic and Metabolic Drugs Advisory Committee Meeting (May 10) Antiviral Drugs Advisory Committee Meeting (May 10) Gastroenterology and Urology Devices Panel of the Medical Devices Advisory Committee Meeting (May 10-11) Antiviral Drugs Advisory Committee Meeting (May 11) Public Hearing on Draft Guidances Relating to the Development of Biosimilar Products (May 11) Preparation for International Conference on Harmonization Steering Committee and Expert Working Group Meetings in Fukuoka, Japan; Regional Public Meeting (May 14) Workshop on Natural History Studies of Rare Diseases (May 16-17) FDA Working with Patients to Explore Benefit/Risk: Opportunities & Challenges (May 18) Circulatory System Devices Panel of the Medical Devices Advisory Committee Meeting (May 24) Peripheral and Central Nervous System Drugs Advisory Committee Meeting (May 24) Scientific Workshop on the Assessment of Analgesic Treatment of Chronic Pain (May 30-31) Regulation of Pharmaceuticals: A Global Perspective (Jun 6-8) Risk Evaluation and Mitigation Strategy (REMS) Assessments: Social Science Methodologies to Assess Goals Related to Knowledge, Public Workshop (Jun 7) RESOURCES:
Articles
Statins: The Story Behind the Label Changes Videos
A Short Tutorial on REMS: The FDA PerspectiveFeaturing Dr. Gerald Dal Pan, Acting Director, FDA Office of Surveillance and Epidemiology in the Center for Drug Evaluation and Research Podcasts Updated information on drug interactions between Victrelis (boceprevir) and certain boosted HIV protease inhibitor drugs Safety review update of cancer drug Revlimid (lenalidomide) and risk of developing new types of malignancies Consumer Updates Indoor Tanning: The Risks of Ultraviolet Rays FDA Voice- the official blog from FDA's senior leadership and staff Six Month Check-Up: FDA’s Work on Drug Shortages (May 3)
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HERE ► Cough: MedlinePlus
Cough
Share on facebookShare on twitter Coughing is a reflex that keeps your throat and airways clear. Although it can be annoying, coughing helps your body heal or protect itself. Coughs can be either acute or chronic. Acute coughs begin suddenly and usually last no more than 2 to 3 weeks. Acute coughs are the kind you most often get with a cold or flu. Chronic coughs last longer than 2 to 3 weeks. Causes of chronic cough include
Asthma
Allergies
COPD (chronic obstructive pulmonary disease)
GERD (gastroesophageal reflux disease)
Smoking
Throat disorders, such as croup in young children
Some medicines
Water can help ease your cough - whether you drink it or add it to the air with a steamy shower or vaporizer. If you have a cold or the flu, antihistamines may work better than non-prescription cough medicines. Children under four should not have cough medicine. For children over four, use caution and read labels carefully.
MEDICAL ENCYCLOPEDIA
Chest x-ray
Cough
Coughing
Coughing up blood
Sputum gram stain
Related Topics
Breathing Problems
Cold and Cough Medicines
Lung Diseases
Whooping Cough
Ear, Nose and Throat
Lungs and Breathing
Symptoms
Living with Cough05/01/2012 08:00 PM EDT Source: National Heart, Lung, and Blood Institute - Cough in Children05/01/2012 08:00 PM EDT Source: American Academy of Allergy, Asthma, and Immunology Chronic Cough in Adults (Beyond the Basics)05/01/2012 08:00 PM EDT Source: UpToDate
DHAP Annual Report: Accelerating Progress, Investing for Impact The Division of HIV/AIDS Prevention recently released its inaugural annual report, Accelerating Progress, Investing for Impact. This report provides an overview of some of the HIV prevention activities conducted and supported by the Centers for Disease Control and Prevention during late 2010 to the end of 2011.Meeting Summary: 2012 Consultation on Revision of the HIV Surveillance Case DefinitionFrom 2008 through 2011, the Centers for Disease Control and Prevention (CDC) convened several workgroups to consider revision of various aspects of the HIV surveillance case definition. On February 7 and 8, 2012, CDC hosted a consultation to consider the recommendations of the workgroups. This document summarizes the workgroup recommendations proposed at the consultation. New Web page: Behavioral and Clinical Surveillance BranchThis new page covers the activities of the Behavioral and Clinical Surveillance Branch in the Division of HIV/AIDS Prevention. This branch implements scientifically rigorous HIV research studies and surveillance systems that meet critical local, state, and national HIV prevention needs for characterizing persons who are at risk for HIV infection or who have recently acquired HIV or have HIV-related illnesses.
If you've been on the hunt for Sprint LTE devices that won't yet function on the carrier's latest 4G network (that, ahem, isn't even scheduled to go live until this summer), May 18th seems to be the day to call in sick. The company's first LTE/WiMAX/3G hotspot will be making its way from the Sierra Wireless manufacturing line to your door for the princely sum of $99.99 (after a $50 rebate and a two-year service agreement) on that date. Data plans range in price from $35 for 3GB to $80 for 12 gigs, on whichever network happens to be available in your area. There's a 3,600 mAh battery on board, which will reportedly keep you online for up to eight hours, along with an Overdrive Pro-like info screen for displaying key stats, like remaining power and your wireless key. You'll find a hearty list of suggested usage scenarios in the press release just past the break, if for some reason you need a PR push to discover just how such a device will fit into your life.
Continue reading Sprint Tri-Fi hotspot boasts LTE, WiMAX and 3G connectivity, set to ship on May 18th
Sprint Tri-Fi hotspot boasts LTE, WiMAX and 3G connectivity, set to ship on May 18th originally appeared on Engadget on Wed, 09 May 2012 11:17:00 EDT. Please see our terms for use of feeds.
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To contact us Click HERE People deal with the pain of online hotel search is different ways. For many, it means spending hours and hours of research spread across dozens of browsers tabs. In my case, I usually throw up your hands and say, "Screw it, I give up, I'm just going to pick an affordable hotel that doesn't look completely terrible." Either way, there's something broken here ? the fact that without being there, it's hard to tell what a hotel is really like. That's the problem that a startup called SimpleHoney wants to solve. It was co-founded by Eric Nakagawa, a software developer who created the famous Icanhascheezburger blog, and Joyce Kim, a former corporate attorney who was previously CEO of Korean pop music site Soompi.com and is probably best-known to the startup community as co-host of the GigaOm Show. The company has raised a seed round from Socialcast and About.me co-founder Tim Young, Mochi Media co-founders Jameson Hsu and Bob Ippolito, former Middleware Company CEO Ed Roman, Causecast founder Ryan Scott, and 500 Startups' Dave McClure. Nakagawa (who's CTO) and Kim (who's CEO) also invested.
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The shaded Coconut Grove house was once the setting for an infamous film.
By Laura Vescey, Zillow
There are homes where famous films were shot that still enjoy a kind of real estate celebrity status all their own. But quite unlike the family-friendly Chicago house used for "Home Alone," a Miami area property where one of the "classics" in adult film history was created is a little less celebrated.
In fact, the listing notes for this Coconut Grove real estate market oddity reflect the notion that the best remedy for it might be, well, a bulldozer. After several price reductions, the 1961 modern is currently priced to sell for $1.75 million, with much of the value resting in the .62 of an acre of land.
Not that one can't imagine there might be a buyer out there who?would actually enjoy remodeling the house where scenes for "Deep Throat" were filmed. According to Miami New Times, the listing photos reveal that rooms where at least two scenes were filmed are clearly visible, including a grotto-like wine cellar:
"Deep Throat, the pioneering 1972 porno film, was partially shot in various places throughout Miami-Dade, and now an infamous mansion that was the setting for two of the film's most infamous scenes is for sale. It can be yours for the price of $1.75 million.
Built and owned by bon vivant Baron Joseph "Sepy" De Bicske Dobronyi, the eccentric house is for sale after the "Baron" died in 2010.
The film follows the plight of Linda Lovelace (playing a fictionalized version of herself), a sexually liberated woman who ... visits a doctor, and well, what do you know? The doctor apparently keeps his office in one of the mansion's cottages."
While the main house needs significant updates, it is an interesting structure with glass walls and unique interior spaces. The property is actually two separate lots, and has a free-form pool that sits below heavy foliage that creates a very private setting -- which makes sense, given the property's cinematic past.
According to Zillow's mortgage calculator, a monthly payment on the Deep Throat home would be $6,441 a month, assuming a 20 percent down payment on a 30 year mortgage.
Zillow
The 5,413-square-foot home has 4 bedrooms and 4 baths.
Zillow
A free-form pool is also on the property.
See more photos of the home on Zillow.
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Related posts: Homes With a Past: Church, Schoolhouse and Silo
House of the Week: Glassy Modern was Rumored Rendezvous Spot for Marilyn and JFK
Beverly Hills Home Where Howard Hughes Crashed for Sale
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Welcome back to our regular column?Android Gaming Weekly, where we recap all the new releases and highlights every Wednesday. We post small bits throughout the week related to Android games, but readers have requested a condensed summary that makes it easier to keep up with all the latest news. Read on for this week?s best in Android gaming.
New Games This Week
Zombro
I smell a sleeper hit. ?Zombro is a puzzle game with a simple goal: Detach Zombro?s basic elements (torso, legs, and braiiiiiinnz) to jump, dodge, and roll while making sure he finishes each level in one piece!? The game features 50 puzzles, 30 items to collect, and you can outfit Zombro in cool gear (plus customize his brain).
JAZZ: Trump?s Journey
We are in New Orleans this week for CTIA Wireless, so I thought it was appropriate to share a game about Jazz music. ?My name is Trump and I?m a jazz man, and this is my story.? This unique platform game?parallels with the real story of Louis Armstrong and follows the birth of jazz.
Ricky Carmichael?s Motorcross
?Ricky Carmichael Motocross Matchup Pro is an all-new racing game where it?s just you against online competitors from around the globe! This includes the chance to bang bars with some the of best in the business, including Ricky Carmichael himself!?
SAS: Zombie Assault 3
Based on the popular flash game by Ninja Kiwi, but completely rebuilt and optimized for Android, SAS: Zombie Assault 3 offers?4 player co-op multiplayer for free. Need I say more?
Ninja Chicken Ooga Booga
Lots of people like Oven Break last week and this title appears to offer similar gameplay. ?Still on a mission to be the best ninja ever, our funky-chicken-who-thinks-he-is-a-ninja has broken free from the farm and into the wilderness!?
Destiny Defense: Angel or Devil
?Destiny Defense: Angel or Devil is the addictive action-strategy defense game with a variety of attack systems and 2 unique storylines. By choosing each side, Angel or Devil, you will be able to feel double thrill and fun as you go through different game plays.?
Zombie Granny
?Zombie Granny is an addictively fun puzzle game that combines zany characters, dazzling animated effects of destruction, and tricky mechanical puzzles for a ghoulishly entertaining good time!?
Android Games Coming Soon
Men in Black 3
Men in Black hits theaters May 25th and Gameloft has a new Android game to coincide with the release. This week they released a teaser video which shows a brief preview, but doesn?t provide many details on the gameplay. Look for Men in Black 3 to debut as a freemium game.
N.O.V.A. 3
Another day, another N.O.V.A. 3 teaser video. This time we get a look at some of the solo mission action. No release date has been given yet, but we expect it to land on select Android devices later this month.
Frontline Commando 2.0
Glu Mobile?s Frontline Commando has already been downloaded over 5 million times, and now they are gearing up to release version 2.0. The latest update should add several new levels, include new powerups, and end with a massive boss battle.
Asphalt 7: Heat
Last week at the Samsung Mobile Unpacked event, Asphalt 7 was briefly teased. This is Gameloft?s most popular racing game, so we have high hopes for the latest chapter in the series. We don?t have many details on the game yet, but we could know more when Samsung releases the Galaxy S III around May 29th.
Max Payne Mobile
Rockstar Games keeps pushing back the release date of Max Payne Mobile for Android, but tomorrow could be the big day. We heard a rumor it could come out at midnight, but Rockstar Games has been quiet on the matter. If you really want this game then check the Google Play store late tonight, but don?t be surprised if it was delayed again.
Games I?m currently playing
Dance Legend: This game came out last month, but I finally took the time to sit down and play it for awhile. I?m not a dancer, but I have always enjoyed music games and Dance Legend was a real blast to play. The game is free and includes several songs to get you started, but additional song packs will cost you money.
NBA Jam: EA Mobile finally updated NBA Jam to support more devices and I?ve been playing it non-stop the last couple days. The controls translate pretty well to a phone or tablet, and it?s just as fun as I remember when I was a little kid. I?m currently playing through the campaign mode trying to defeat every team and unlock big head mode. We are crossing our fingers that EA will eventually add an online multiplayer mode.
What Android games are you playing?
Find any great new Android games this week? Share your favorites in the comments below so we can check them out.
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To contact us Click HERE AGU: Groundwater pumping leads to sea level rise, cancels out effect of damsPublic release date: 8-May-2012 [ | E-mail | Share ]
Contact: Kate Ramsayer kramsayer@agu.org 202-777-7524 American Geophysical Union
WASHINGTON -- As people pump groundwater for irrigation, drinking water, and industrial uses, the water doesn't just seep back into the ground it also evaporates into the atmosphere, or runs off into rivers and canals, eventually emptying into the world's oceans. This water adds up, and a new study calculates that by 2050, groundwater pumping will cause a global sea level rise of about 0.8 millimeters per year.
"Other than ice on land, the excessive groundwater extractions are fast becoming the most important terrestrial water contribution to sea level rise," said Yoshihide Wada, with Utrecht University in the Netherlands and lead author of the study. In the coming decades, he noted, groundwater contributions to sea level rise are expected to become as significant as those of melting glaciers and ice caps outside of Greenland and the Antarctic.
Between around 1970 and 1990, sea level rise caused by groundwater pumping was cancelled out as people built dams, trapping water in reservoirs so the water wouldn't empty into the sea, Wada said. His research shows that starting in the 1990s, that changed as populations started pumping more groundwater and building fewer dams.
The researchers looked not only at the contribution of groundwater pumping, which they had investigated before, but also at other factors that influence the amount of terrestrial water entering the oceans, including marsh drainage, forest clearing, and new reservoirs. Wada and his colleagues calculate that by mid-century, the net effect of these additional factors is an additional 0.05 mm per year of annual sea level rise, on top of the contribution from groundwater pumping alone.
The research team's article is being published today in Geophysical Research Letters, a journal of the American Geophysical Union.
The last report of the United Nations Intergovernmental Panel on Climate Change in 2007 addressed the effect on sea level rise of melting ice on land, including glaciers and ice caps, Wada said. But it didn't quantify the future contribution from other terrestrial water sources, such as groundwater, reservoirs, wetlands and more, he said, because the report's authors thought the estimates for those sources were too uncertain.
"They assumed that the positive and negative contribution from the groundwater and the reservoirs would cancel out," Wada said. "We found that wasn't the case. The contribution from the groundwater is going to increase further, and outweigh the negative contribution from reservoirs."
In the current study, the researchers estimated the impact of groundwater depletion since 1900 using data from individual countries on groundwater pumping, model simulations of groundwater recharge, and reconstructions of how water demand has changed over the years. They also compared and corrected those estimates with observations from sources such as the GRACE satellite, which uses gravity measurements to determine variations in groundwater storage.
With these groundwater depletion rates, Wada and his colleagues estimate that in 2000, people pumped about 204 cubic kilometers (49 cubic miles) of groundwater, most of which was used for irrigation. Most of this, in turn, evaporates from plants, enters the atmosphere and rains back down. Taking into account the seepage of groundwater back into the aquifers, as well as evaporation and runoff, the researchers estimated that groundwater pumping resulted in sea level rise of about 0.57 mm in 2000 much greater than the 1900 annual sea level rise of 0.035 mm.
The researchers also projected groundwater depletion, reservoir storage, and other impacts for the rest of the century, using climate models and projected population growth and land use changes. The increase in groundwater depletion between 1900 and 2000 is due mostly to increased water demands, the researchers find. But the increase projected between 2000 and 2050 is mostly due to climate-related factors like decreased surface water availability and irrigated agricultural fields that dry out faster in a warmer climate.
If things continue as projected, Wada estimates that by 2050, the net, cumulative effect of these non-ice, land-based water sources and reservoirs -- including groundwater pumping, marsh drainage, dams, and more -- will have added 31 mm to sea level rise since 1900.
The new study assumes that, where there is groundwater, people will find a way to extract it, Wada said, but some of his colleagues are investigating the limits of groundwater extraction. One way to decrease groundwater's contribution to sea level rise, he noted, is to improve water efficiency in agriculture -- to grow more with less groundwater.
###
Notes for Journalists
Journalists and public information officers (PIOs) of educational and scientific institutions
who have registered with AGU can download a PDF copy of this paper in press by
clicking on this link:
http://www.agu.org/pubs/crossref/2012/2012GL051230.shtml
Or, you may order a copy of the final paper by emailing your request to Kate Ramsayer at
kramsayer@agu.org. Please provide your name, the name of your publication, and your phone
number.
Neither the paper nor this press release are under embargo.
Title:
"Past and future contribution of global groundwater depletion to sea-level rise"
Authors:
Yoshihide Wada: Department of Physical Geography, Utrecht University, Utrecht, Netherlands;
Ludovicus P. H. van Beek: Department of Physical Geography, Utrecht University, Utrecht,
Netherlands;
Frederiek C. Sperna Weiland: Deltares, Delft, Netherlands;
Benjamin F. Chao and Yun-Hao Wu: Institute of Earth Sciences, Academia Sinica, Taipei,
Taiwan;
Marc F. P. Bierkens: Department of Physical Geography, Utrecht University, Utrecht,
Netherlands, Unit Soil and Groundwater Systems, Deltares, Utrecht, Netherlands.
Contact Information for the Authors:
Yoshihide Wada, Email: y.wada@uu.nl, Telephone: +31 (0)30 253 2776
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
AGU: Groundwater pumping leads to sea level rise, cancels out effect of damsPublic release date: 8-May-2012 [ | E-mail | Share ]
Contact: Kate Ramsayer kramsayer@agu.org 202-777-7524 American Geophysical Union
WASHINGTON -- As people pump groundwater for irrigation, drinking water, and industrial uses, the water doesn't just seep back into the ground it also evaporates into the atmosphere, or runs off into rivers and canals, eventually emptying into the world's oceans. This water adds up, and a new study calculates that by 2050, groundwater pumping will cause a global sea level rise of about 0.8 millimeters per year.
"Other than ice on land, the excessive groundwater extractions are fast becoming the most important terrestrial water contribution to sea level rise," said Yoshihide Wada, with Utrecht University in the Netherlands and lead author of the study. In the coming decades, he noted, groundwater contributions to sea level rise are expected to become as significant as those of melting glaciers and ice caps outside of Greenland and the Antarctic.
Between around 1970 and 1990, sea level rise caused by groundwater pumping was cancelled out as people built dams, trapping water in reservoirs so the water wouldn't empty into the sea, Wada said. His research shows that starting in the 1990s, that changed as populations started pumping more groundwater and building fewer dams.
The researchers looked not only at the contribution of groundwater pumping, which they had investigated before, but also at other factors that influence the amount of terrestrial water entering the oceans, including marsh drainage, forest clearing, and new reservoirs. Wada and his colleagues calculate that by mid-century, the net effect of these additional factors is an additional 0.05 mm per year of annual sea level rise, on top of the contribution from groundwater pumping alone.
The research team's article is being published today in Geophysical Research Letters, a journal of the American Geophysical Union.
The last report of the United Nations Intergovernmental Panel on Climate Change in 2007 addressed the effect on sea level rise of melting ice on land, including glaciers and ice caps, Wada said. But it didn't quantify the future contribution from other terrestrial water sources, such as groundwater, reservoirs, wetlands and more, he said, because the report's authors thought the estimates for those sources were too uncertain.
"They assumed that the positive and negative contribution from the groundwater and the reservoirs would cancel out," Wada said. "We found that wasn't the case. The contribution from the groundwater is going to increase further, and outweigh the negative contribution from reservoirs."
In the current study, the researchers estimated the impact of groundwater depletion since 1900 using data from individual countries on groundwater pumping, model simulations of groundwater recharge, and reconstructions of how water demand has changed over the years. They also compared and corrected those estimates with observations from sources such as the GRACE satellite, which uses gravity measurements to determine variations in groundwater storage.
With these groundwater depletion rates, Wada and his colleagues estimate that in 2000, people pumped about 204 cubic kilometers (49 cubic miles) of groundwater, most of which was used for irrigation. Most of this, in turn, evaporates from plants, enters the atmosphere and rains back down. Taking into account the seepage of groundwater back into the aquifers, as well as evaporation and runoff, the researchers estimated that groundwater pumping resulted in sea level rise of about 0.57 mm in 2000 much greater than the 1900 annual sea level rise of 0.035 mm.
The researchers also projected groundwater depletion, reservoir storage, and other impacts for the rest of the century, using climate models and projected population growth and land use changes. The increase in groundwater depletion between 1900 and 2000 is due mostly to increased water demands, the researchers find. But the increase projected between 2000 and 2050 is mostly due to climate-related factors like decreased surface water availability and irrigated agricultural fields that dry out faster in a warmer climate.
If things continue as projected, Wada estimates that by 2050, the net, cumulative effect of these non-ice, land-based water sources and reservoirs -- including groundwater pumping, marsh drainage, dams, and more -- will have added 31 mm to sea level rise since 1900.
The new study assumes that, where there is groundwater, people will find a way to extract it, Wada said, but some of his colleagues are investigating the limits of groundwater extraction. One way to decrease groundwater's contribution to sea level rise, he noted, is to improve water efficiency in agriculture -- to grow more with less groundwater.
###
Notes for Journalists
Journalists and public information officers (PIOs) of educational and scientific institutions
who have registered with AGU can download a PDF copy of this paper in press by
clicking on this link:
http://www.agu.org/pubs/crossref/2012/2012GL051230.shtml
Or, you may order a copy of the final paper by emailing your request to Kate Ramsayer at
kramsayer@agu.org. Please provide your name, the name of your publication, and your phone
number.
Neither the paper nor this press release are under embargo.
Title:
"Past and future contribution of global groundwater depletion to sea-level rise"
Authors:
Yoshihide Wada: Department of Physical Geography, Utrecht University, Utrecht, Netherlands;
Ludovicus P. H. van Beek: Department of Physical Geography, Utrecht University, Utrecht,
Netherlands;
Frederiek C. Sperna Weiland: Deltares, Delft, Netherlands;
Benjamin F. Chao and Yun-Hao Wu: Institute of Earth Sciences, Academia Sinica, Taipei,
Taiwan;
Marc F. P. Bierkens: Department of Physical Geography, Utrecht University, Utrecht,
Netherlands, Unit Soil and Groundwater Systems, Deltares, Utrecht, Netherlands.
Contact Information for the Authors:
Yoshihide Wada, Email: y.wada@uu.nl, Telephone: +31 (0)30 253 2776
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
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Mobile Clinic and In-Home Educator Generate Small, Short-Term Increases in Symptom-Free Days in Inner-City Preschool Children With Asthma But No Improvements in Other Key Outcomes 
Disease Management Programs Improve Adherence to Evidence-Based Processes and Outcomes by Targeting Sickest Patients and Working Closely With Physicians 
full-text ► 
Cough in Children05/01/2012 08:00 PM EDT
People deal with the pain of online hotel search is different ways. For many, it means spending hours and hours of research spread across dozens of browsers tabs. In my case, I usually throw up your hands and say, "Screw it, I give up, I'm just going to pick an affordable hotel that doesn't look completely terrible." Either way, there's something broken here ? the fact that without being there, it's hard to tell what a hotel is really like. That's the problem that a startup called SimpleHoney wants to solve. It was co-founded by Eric Nakagawa, a software developer who created the famous Icanhascheezburger blog, and Joyce Kim, a former corporate attorney who was previously CEO of Korean pop music site Soompi.com and is probably best-known to the startup community as co-host of the GigaOm Show. The company has raised a seed round from Socialcast and About.me co-founder Tim Young, Mochi Media co-founders Jameson Hsu and Bob Ippolito, former Middleware Company CEO Ed Roman, Causecast founder Ryan Scott, and 500 Startups' Dave McClure. Nakagawa (who's CTO) and Kim (who's CEO) also invested.
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Public release date: 8-May-2012
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